Article

Low- and high-grade glioma endothelial cells differentially regulate tumor growth

2023-07-07

Abstract excerpt

<h4>Background</h4> A key feature distinguishing high-grade glioma (HGG) from low-grade glioma (LGG) is the extensive neovascularization and endothelial hyperproliferation. Prior work has shown that tumor endothelial cells (TEC) from HGG are molecularly and functionally distinct from normal brain EC and secrete higher levels of pro-tumorigenic factors that promote glioma growth and progression. However, it remain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10050844-b2fd-5c6d-9b9a-32aa20765c2a
DOI: 10.1101/2023.07.07.548125

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low- and high-grade glioma endothelial cells differentially regulate tumor growthDOI 10.1101/2023.07.07.548125Read

Low- and High-Grade Glioma-Associated Vascular Cells Differentially Regulate Tumor Growth.Semantic proximity Read

Identification of diverse tumor endothelial cell populations in malignant gliomaSemantic proximity Read

IDH mutation status is associated with distinct vascular gene expression signatures in lower-grade gliomas.Semantic proximity Read

Hypoxia drives shared and distinct transcriptomic changes in two invasive glioma stem cell linesSemantic proximity Read

The genetic status of IDH1/2 and EGFR dictates the vascular landscape and the progression of gliomasSemantic proximity Read

Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel TreatmentsSemantic proximity Read

3D Brain Vascular Niche Model Captures Invasive Behavior and Gene Signatures of GlioblastomaSemantic proximity Read

A Novel Anoikis-Related Gene Signature Predicts Prognosis in Patients with Low-Grade Glioma and Reveals Immune InfiltrationSemantic proximity Read

Upregulated functional gene expression programmes in tumour pericytes mark progression in patients with low‐grade gliomaSemantic proximity Read

3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene SignaturesSemantic proximity Read

Vascular Transdifferentiation in the CNS: A Focus on Neural and Glioblastoma Stem‐Like CellsSemantic proximity Read

Characteristics of tumor-associated endothelial cells derived from glioblastoma multiformeSemantic proximity Read