Article

A biomimetic five-module chimeric antigen receptor ( <sup>5M</sup> CAR) designed to target and eliminate antigen-specific T cells

2020-01-25

Abstract excerpt

T cells express clonotypic T cell receptors (TCRs) that recognize peptide antigens in the context of class I or II MHC molecules (pMHCI/II). These receptor modules associate with three signaling modules (CD3γε, δε, and ζζ), and work in concert with a coreceptor module (either CD8 or CD4), to drive T cell activation in response to pMHCI/II. Here we describe a first generation biomimetic 5-module chimeric antigen re...

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Identifiers and source

Literature Corpus work: 0ff07c6d-f366-5658-9f59-41fe869f5b3b
DOI: 10.1101/2020.01.24.916932

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