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MTHFR variants 677TT and 677CT/1298AC are associated with decreased tolerance to methotrexate in pediatric acute lymphoblastic leukemia

2022-11-03

Abstract excerpt

<h4>Background: </h4> Methotrexate (MTX) remains a critical component in the treatment of pediatric acute lymphoblastic leukemia (ALL), exerting its antileukemic effect through interference of the folate metabolic pathway. MTHFR is an enzyme that serves as the rate limiting step within this pathway and there has been speculation that certain MTHFR single nucleotide polymorphisms (SNPs) alter physiologic responses...

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Literature Corpus work
0fd68974-eaf2-5326-82a6-9e0a54ee9f0f
DOI
10.22541/au.166745891.13248632/v1
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MTHFR variants 677TT and 677CT/1298AC are associated with decreased tolerance to methotrexate in pediatric acute lymphoblastic leukemiaDOI 10.22541/au.166745891.13248632/v1
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