Article
High dose methotrexate treatment in childhood ALL: pilot study on the impact of the MTHFR 677C>T and 1298A>C polymorphisms on MTX-related toxicity.
Klinische Padiatrie - 1 Apr 2012
Haase R, Elsner K, Merkel N, Stiefel M, Mauz-Körholz C, Kramm C M, Körholz D
Abstract excerpt
Methotrexate (MTX) is commonly administered in high doses for treatment of childhood acute lymphoblastic leukemia (ALL). The aim of this analysis was to study the influence of 2 common MTHFR polymorphisms (MTHFR 677C>T and 1298 A>C) on MTX toxicity in children with ALL.Retrospective analysis of 129 MTX courses in 34 pediatric patients with ALL.677C>T variants (CT or TT) were found in 19 (14 heterozygous, 5...
Topics
- Alleles
- Antimetabolites, Antineoplastic
- Child
- Child, Preschool
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Female
- Genetic Carrier Screening
- Genotype
- Homozygote
- Humans
- Leukopenia
- Male