Article

Deep Whole Genome Sequencing Identifies Recurrent Genomic Alterations in Commonly-Used Breast Cancer Cell Lines and Patient Derived Xenograft Models

2021-09-30

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Breast cancer cell lines (BCCLs) and patient-derived xenografts (PDX) are the most frequently used models in breast cancer research. Despite their widespread usage, genome sequencing of these models is incomplete, with previous studies only focusing on targeted gene panels, whole exome or shallow whole genome sequencing. Deep whole genome sequencing is the most...

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Literature Corpus work: 0fbf8ee1-cab1-5d33-9d7f-6bc1e260c47a
DOI: 10.21203/rs.3.rs-859624/v2

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