Article
Sequence analysis of mutations and translocations across breast cancer subtypes.
Nature - 20 Jun 2012
Banerji Shantanu, Cibulskis Kristian, Rangel-Escareno Claudia, Brown Kristin K, Carter Scott L, Frederick Abbie M, Lawrence Michael S, Sivachenko Andrey Y, Sougnez Carrie, Zou Lihua, Cortes Maria L, Fernandez-Lopez Juan C, Peng Shouyong, Ardlie Kristin G, Auclair Daniel, Bautista-Piña Veronica, Duke Fujiko, Francis Joshua, Jung Joonil, Maffuz-Aziz Antonio, Onofrio Robert C, Parkin Melissa, Pho Nam H, Quintanar-Jurado Valeria, Ramos Alex H, Rebollar-Vega Rosa, Rodriguez-Cuevas Sergio, Romero-Cordoba Sandra L, Schumacher Steven E, Stransky Nicolas, Thompson Kristin M, Uribe-Figueroa Laura, Baselga Jose, Beroukhim Rameen, Polyak Kornelia, Sgroi Dennis C, Richardson Andrea L, Jimenez-Sanchez Gerardo, Lander Eric S, Gabriel Stacey B, Garraway Levi A, Golub Todd R, Melendez-Zajgla Jorge, Toker Alex, Getz Gad, Hidalgo-Miranda Alfredo, Meyerson Matthew
Abstract excerpt
Breast carcinoma is the leading cause of cancer-related mortality in women worldwide, with an estimated 1.38 million new cases and 458,000 deaths in 2008 alone. This malignancy represents a heterogeneous group of tumours with characteristic molecular features, prognosis and responses to available therapy. Recurrent somatic alterations in breast cancer have been described, including mutations and copy number...
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