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Within-host diversity of <i>Mycobacterium tuberculosis</i> : weak host association and no transmission signal in a Ghanaian cohort

2026-06-01

Abstract excerpt

<h4>Background</h4> Within host diversity (WHD) in Mycobacterium tuberculosis is increasingly used to infer transmission and treatment response, but it lies at low allele frequencies where sequencing error and reference mapping artifact can be mistaken for signal. <h4>Methods</h4> In a cohort in Accra, Ghana, we measured WHD using deep short read whole genome sequencing and LoFreq with a depth-conditional dete...

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Literature Corpus work
0f3a3e57-f484-593a-8575-ac776fe79d79
DOI
10.64898/2026.05.27.727477
Open publication

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Within-host diversity of <i>Mycobacterium tuberculosis</i> : weak host association and no transmission signal in a Ghanaian cohortDOI 10.64898/2026.05.27.727477
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