Signatures of transmission in within-host Mycobacterium tuberculosis complex variation: a retrospective genomic epidemiology study.

doi:10.1016/j.lanmic.2024.06.003

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Article

Signatures of transmission in within-host Mycobacterium tuberculosis complex variation: a retrospective genomic epidemiology study.

The Lancet. Microbe - 1 Jan 2025

Walter Katharine S, Cohen Ted, Mathema Barun, Colijn Caroline, Sobkowiak Benjamin, Comas Iñaki, Goig Galo A, Croda Julio, Andrews Jason R

Abstract excerpt

BACKGROUND: Mycobacterium tuberculosis complex (MTBC) species evolve slowly, so isolates from individuals linked in transmission often have identical or nearly identical genomes, making it difficult to reconstruct transmission chains. Finding additional sources of shared MTBC variation could help overcome this problem. Previous studies have reported MTBC diversity within infected individuals; however, whether...

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Topics

Humans
Retrospective Studies
Mycobacterium tuberculosis
Tuberculosis
Genetic Variation
Whole Genome Sequencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome, Bacterial

Genomics

Female

Male

Family Characteristics

Molecular Epidemiology

Gene Frequency

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Identifiers

PMID: 39615498
DOI: 10.1016/j.lanmic.2024.06.003
PMCID: PMC11777664

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