Article

Nociceptin receptor and ligand in Alzheimer’s disease: Implications for psychiatric symptoms and circadian regulation

2025-06-08

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Nociceptin (N/OFQ) and its receptor OPRL1 play crucial roles in emotional processing, reward-related behaviors, learning, and neurotransmitter regulation, but their involvement in Alzheimer’s disease (AD) pathology remains poorly understood. This study investigated possible relationships between prepronociceptin ( PNOC ) and OPRL1 expression and psychiatric symptoms in AD,...

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Literature Corpus work: d556f36a-60e5-5fa1-b7cb-f685f191bd2a
DOI: 10.1101/2025.06.04.657953

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