Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli.

Innate immunity - 1 Nov 2016

Chuang Yishan, Hung Michelle E, Cangelose Brianne K, Leonard Joshua N

Abstract excerpt

Macrophages are ubiquitous innate immune cells that play a central role in health and disease by adopting distinct phenotypes, which are broadly divided into classical inflammatory responses and alternative responses that promote immune suppression and wound healing. Although macrophages are attractive therapeutic targets, incomplete understanding of this functional choice limits clinical manipulation. While...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Feedback, Physiological
Share to Immunity, Innate
Share to Immunosuppression Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-gamma

Share to Interleukin-10

Share to Interleukin-12

Share to Macrophages

Share to RAW 264.7 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 27670945
DOI: 10.1177/1753425916668243
PMCID: PMC5292318

Genes

BCL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli.PMID 27670945Read ↗

Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and DiseaseSemantic proximity Read ↗

Macrophages in Ulcerative Colitis: Immunomodulatory Roles, Phenotypic Switching, and Therapeutic Targeting.Semantic proximity Read ↗

Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences.Semantic proximity Read ↗

Regulation of macrophage phenotype by long-term exposure to IL-10.Semantic proximity Read ↗

Knock-down of a regulatory barcode shifts macrophage polarization destination from M1 to M2 and increases pathogen burden upon <i>S. aureus</i> infectionSemantic proximity Read ↗

Interferon-regulatory factors determine macrophage phenotype polarization.Semantic proximity Read ↗

Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage "Switch" Phenotype.Semantic proximity Read ↗

Casein Kinase 2 Interacting Protein-1 regulates M1 and M2 inflammatory macrophage polarization.Semantic proximity Read ↗

The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling.Semantic proximity Read ↗

Interferon-β paracrine signaling mediates synergy between TLR3 and TRIF-independent TLR pathwaysSemantic proximity Read ↗

Tissue microenvironments define and get reinforced by macrophage phenotypes in homeostasis or during inflammation, repair and fibrosis.Semantic proximity Read ↗

Bistability in macrophage polarization and metabolic implicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.