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Article

An Oxidative Stress‐Related Gene Signature in Granulosa Cells Is Associated with Ovarian Aging

1 Jan 2022

Abstract excerpt

Ovarian aging is associated with a decrease in fecundity. Increased oxidative stress of granulosa cells (GCs) is an important contributor. We thus asked whether there is an oxidative stress‐related gene signature in GCs associated with ovarian aging. Public nonhuman primate (NHP) single‐cell transcriptome was processed to identify GC cluster. Then, a GC signature for ovarian aging was established based on six...

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PMID: 36466095
DOI: 10.1155/2022/1070968

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