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Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice

18 Oct 2016

Abstract excerpt

mice, metformin delayed the onset of tumors and significantly extended the tumor-free survival time. In addition, we found that metformin and the structurally related compound aminoguanidine reduced DNA damage and ameliorated spontaneous chromosome breakage and radials in human FA patient-derived cells. Our results also indicate that aldehyde detoxification might be one of the mechanisms by which metformin...

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PMID: 27756748
DOI: 10.1182/blood-2015-11-683490

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