Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oxymetholone Therapy of Fanconi Anemia Suppresses Osteopontin Transcription and Induces Hematopoietic Stem Cell Cycling

26 Nov 2014

Abstract excerpt

Androgens are widely used for treating Fanconi anemia (FA) and other human bone marrow failure syndromes, but their mode of action remains incompletely understood. Aged Fancd2(-/-) mice were used to assess the therapeutic efficacy of oxymetholone (OXM) and its mechanism of action. Eighteen-month-old Fancd2(-/-) mice recapitulated key human FA phenotypes, including reduced bone marrow cellularity, red cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Erythrocyte Function and Pathophysiology
Share to Hematopoietic Stem Cell Transplantation
Share to Mesenchymal stem cell research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25434823
DOI: 10.1016/j.stemcr.2014.10.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oxymetholone Therapy of Fanconi Anemia Suppresses Osteopontin Transcription and Induces Hematopoietic Stem Cell CyclingPMID 25434823Read ↗

Treatment Overview of Fanconi Anemia and Other Inherited Bone Marrow Failure SyndromesSemantic proximity Read ↗

The transcriptomic landscape of normal and ineffective erythropoiesis at single cell resolutionSemantic proximity Read ↗

Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.Semantic proximity Read ↗

Long-term combination therapy with Metformin and Oxymetholone in a Fanconi Anemia mouse modelSemantic proximity Read ↗

Mesenchymal stem/stromal cells from a transplanted, asymptomatic patient with Fanconi anemia exhibit an aging-like phenotype and dysregulated expression of genes implicated in hematopoiesis and myelodysplasia.Semantic proximity Read ↗

Haematopoietic gene therapy of non-conditioned patients with Fanconi anaemia-A: results from open-label phase 1/2 (FANCOLEN-1) and long-term clinical trialsSemantic proximity Read ↗

Fancd2 −/− mice have hematopoietic defects that can be partially corrected by resveratrolSemantic proximity Read ↗

Steroid resistance in Diamond Blackfan anemia associates with p57Kip2 dysregulation in erythroid progenitorsSemantic proximity Read ↗

An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in Fanconi anemiaSemantic proximity Read ↗

Phase 1 study of quercetin, a natural antioxidant for children and young adults with Fanconi anemiaSemantic proximity Read ↗

Single-cell transcriptome sequencing reveals the mechanism of Realgar improvement on erythropoiesis in mice with myelodysplastic syndromeSemantic proximity Read ↗

Comprehensive characterization of mesenchymal stromal cells from patients with Fanconi anaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.