Article

Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis

2018-01-11

Abstract excerpt

The earliest developmental origins of dysmorphologies are poorly understood in many congenital diseases. They often remain elusive because the first signs of genetic misregulation may initiate as subtle changes in gene expression, which can be obscured later in development due to secondary phenotypic effects. We here develop a method to trace back the origins of phenotypic abnormalities by accurately quantifying t...

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Literature Corpus work: 0ef01697-9b7b-5772-b191-146472febb74
DOI: 10.1101/246256

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