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Article

Automated deep-phenotyping of the vertebrate brain.

eLife - 13 Apr 2017

Allalou Amin, Wu Yuelong, Ghannad-Rezaie Mostafa, Eimon Peter M, Yanik Mehmet Fatih

Abstract excerpt

Here, we describe an automated platform suitable for large-scale deep-phenotyping of zebrafish mutant lines, which uses optical projection tomography to rapidly image brain-specific gene expression patterns in 3D at cellular resolution. Registration algorithms and correlation analysis are then used to compare 3D expression patterns, to automatically detect all statistically significant alterations in mutants, and...

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Identifiers

PMID: 28406399
DOI: 10.7554/eLife.23379
PMCID: PMC5441873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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