Article
Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage.
Disease models & mechanisms - 1 Jan 2015
Green Rebecca M, Feng Weiguo, Phang Tzulip, Fish Jennifer L, Li Hong, Spritz Richard A, Marcucio Ralph S, Hooper Joan, Jamniczky Heather, Hallgrímsson Benedikt, Williams Trevor
Abstract excerpt
Failure of facial prominence fusion causes cleft lip and palate (CL/P), a common human birth defect. Several potential mechanisms can be envisioned that would result in CL/P, including failure of prominence growth and/or alignment as well as a failure of fusion of the juxtaposed epithelial seams. Here, using geometric morphometrics, we analyzed facial outgrowth and shape change over time in a novel mouse model...
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