Article
Phenotypic variability and craniofacial dysmorphology: increased shape variance in a mouse model for cleft lip.
Journal of anatomy - 1 Feb 2008
Parsons Trish E, Kristensen Erika, Hornung Lynnette, Diewert Virginia M, Boyd Steven K, German Rebecca Z, Hallgrímsson Benedikt
Abstract excerpt
Cleft lip and palate (CL/P), as is true of many craniofacial malformations in humans, is etiologically complex and highly variable in expression. A/WySn mice are an intriguing model for human CL/P because they develop this dysmorphology with a variable expression pattern, incomplete penetrance and frequent unilateral expression on a homogeneous genetic background. The developmental basis for this variation in...
Topics
- Animals
- Cleft Lip
- Cleft Palate
- Craniofacial Abnormalities
- Disease Models, Animal
- Embryonic Development
- Mice
- Mice, Inbred C57BL
- Phenotype
- Statistics as Topic
- Tomography Scanners, X-Ray Computed