Article
Complex haplotypes of metabolizing <i>GSTM1</i> gene deletion harbors signatures of a selective sweep in East Asian populations
2018-03-23
Abstract excerpt
<h4>ABSTRACT</h4> The deletion of the metabolizing Glutathione S-transferase Mu 1 ( GSTM1 ) gene was previously associated with multiple cancers, metabolic and autoimmune disorders, as well as drug response. It is unusually common, with allele frequency reaching up to 75% in some human populations. Such high allele frequency of a derived allele with apparent impact on an otherwise conserved gene is a rare phenom...
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Identifiers and source
- Literature Corpus work
- 0ee95231-bb07-5fc0-9044-720074ee6cc9
- DOI
- 10.1101/287417