Article

Long-Term Exposure of Cells to Cdk4 Inhibitor Palbociclib Leads to Chromosomal Aberrations

2023-08-11

Abstract excerpt

Breast cancers are often driven by mutations, alterations and activation of cell cycle regulatory proteins, including the retinoblastoma tumor suppressor protein (Rb), cyclin E and cyclin-dependent kinases (Cdks), especially cyclin D:Cdk4/6 complexes. There are currently three FDA approved Cdk4/6 inhibitors (Cdk4i) for treating breast cancer. The standard treatment protocol is 21 days of continuous Cdk4i treatment...

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Literature Corpus work: 0ee5a946-6740-58bb-b731-3c3dcd7a0fc0
DOI: 10.1101/2023.08.10.552830

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Long-Term Exposure of Cells to Cdk4 Inhibitor Palbociclib Leads to Chromosomal AberrationsDOI 10.1101/2023.08.10.552830Read

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