Article

Release from cell cycle arrest with Cdk4/6 inhibitors generates highly synchronised cell cycle progression in human cell culture

2020-07-04

Abstract excerpt

Each approach used to synchronise cell cycle progression of human cell lines presents a unique set of challenges. Induction synchrony with agents that transiently block progression through key cell cycle stages are popular, but change stoichiometries of cell cycle regulators, invoke compensatory changes in growth rate and, for DNA replication inhibitors, damage DNA. The production, replacement, or manipulation of...

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Literature Corpus work: 813e435d-bdbd-5491-94eb-e495588af62f
DOI: 10.1101/2020.07.04.187625

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