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Article

Centrosome aberration accompanied with p53 mutation can induce genetic instability in hepatocellular carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2004

Nakajima Tomoki, Moriguchi Michihisa, Mitsumoto Yasuhide, Sekoguchi Satoru, Nishikawa Taichirou, Takashima Hidetaka, Watanabe Tadashi, Katagishi Tatsuo, Kimura Hiroyuki, Okanoue Takeshi, Kagawa Keizo

Abstract excerpt

Centrosome duplication is controlled in a cell cycle-specific manner and occurs once every cell cycle, thereby ensuring the balanced segregation of chromosomes during the mitotic phase. Numerical or structural abnormalities can arise in the centrosomes of malignant cells. Under defective cell cyc...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15044920
DOI: 10.1038/modpathol.3800115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15044920-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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