Article
Centrosome aberration accompanied with p53 mutation can induce genetic instability in hepatocellular carcinoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2004
Nakajima Tomoki, Moriguchi Michihisa, Mitsumoto Yasuhide, Sekoguchi Satoru, Nishikawa Taichirou, Takashima Hidetaka, Watanabe Tadashi, Katagishi Tatsuo, Kimura Hiroyuki, Okanoue Takeshi, Kagawa Keizo
Abstract excerpt
Centrosome duplication is controlled in a cell cycle-specific manner and occurs once every cell cycle, thereby ensuring the balanced segregation of chromosomes during the mitotic phase. Numerical or structural abnormalities can arise in the centrosomes of malignant cells. Under defective cell cycle checkpoint systems, cancer cells with abnormal centrosomes can survive and re-enter the cell cycle, promoting...
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