Article

Tumors widely express hundreds of embryonic germline genes

2020-09-09

Abstract excerpt

We have recently described a class of 756 genes that are widely expressed in cancer, while normally restricted to adult germ cells, referred to as germ cell cancer genes (GC-genes). We hypothesized that carcinogenesis involves reactivation of biomolecular processes and regulatory mechanisms that, under normal circumstances, are restricted to germline development. This would imply that cancer cells share gene expre...

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Literature Corpus work: 0ec2bc3e-2326-5108-bd52-51390211e830
DOI: 10.1101/2020.09.08.287284

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