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Article

Molecular genetic evidence supporting diverse histogenic origins of germ cell tumors

25 Sept 2021

Abstract excerpt

Germ cell tumors (GCTs) originate during the histogenesis of primordial germ cells to mature gametes. Previous studies identified five histogenic mechanisms in ovarian mature teratomas (type I: failure of meiosis I; type II: failure of meiosis II; type III: duplication of the genome of a mature gamete; type IV: no meiosis; and type V: fusion of two different ova), but those of other GCTs remain elusive. In this...

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PMID: 34561860
DOI: 10.1002/path.5799

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