Article

<i>MEG3</i> Enhances Survival of Developing Human Neurons with <i>CLCN4</i> -Linked Autophagy Impairment

2025-07-19

Abstract excerpt

Genetic variations in CLCN4 , encoding the H + /Cl - exchanger CLC-4, are associated with human neurodevelopmental disorders with highly variable phenotypes. A lack of physiologically relevant models has hampered molecular understanding of pathogenic mechanisms. We now establish engineered brain organoid and neuronal cell systems to examine impacts of patient-relevant CLCN4 genetic variations. We find that CL...

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Literature Corpus work: 0787e6d4-3b0d-5545-9d01-8a62cfb8f384
DOI: 10.1101/2025.07.16.665078

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