Article

Greater Mitochondrial DNA Pathogenicity is Associated with Greater Regional Cerebral Blood Flow in Youth Bipolar Disorder

2025-10-20

Abstract excerpt

<title>Abstract</title> <p> Mitochondrial dysfunction is implicated in the neuropathology of bipolar disorder (BD). Mitochondrial DNA (mtDNA) variants are associated with anomalous cerebral energy metabolism and with increased risk for BD. Little is known about the relevance of mtDNA to cerebral blood flow (CBF) in BD. Participants included 101 youth (BD, n = 56; Control group, n = 45; ages 13–20). The Miseq pla...

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Literature Corpus work: 0e7d1188-59fe-592d-8c68-80fc7c5e38d4
DOI: 10.21203/rs.3.rs-7635750/v1

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