Article
Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder.
PloS one - 1 Jan 2009
Rollins Brandi, Martin Maureen V, Sequeira P Adolfo, Moon Emily A, Morgan Ling Z, Watson Stanley J, Schatzberg Alan, Akil Huda, Myers Richard M, Jones Edward G, Wallace Douglas C, Bunney William E, Vawter Marquis P
Abstract excerpt
BACKGROUND: Mitochondria provide most of the energy for brain cells by the process of oxidative phosphorylation. Mitochondrial abnormalities and deficiencies in oxidative phosphorylation have been reported in individuals with schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) in transcriptomic, proteomic, and metabolomic studies. Several mutations in mitochondrial DNA (mtDNA) sequence...
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