Article
A human brain map of mitochondrial respiratory capacity and diversity.
Nature - 1 May 2025
Mosharov Eugene V, Rosenberg Ayelet M, Monzel Anna S, Osto Corey A, Stiles Linsey, Rosoklija Gorazd B, Dwork Andrew J, Bindra Snehal, Junker Alex, Zhang Ya, Fujita Masashi, Mariani Madeline B, Bakalian Mihran, Sulzer David, De Jager Philip L, Menon Vilas, Shirihai Orian S, Mann J John, Underwood Mark D, Boldrini Maura, Thiebaut de Schotten Michel, Picard Martin
Abstract excerpt
Mitochondrial oxidative phosphorylation (OXPHOS) powers brain activity1,2, and mitochondrial defects are linked to neurodegenerative and neuropsychiatric disorders3,4. To understand the basis of brain activity and behaviour, there is a need to define the molecular energetic landscape of the brain5-10. Here, to bridge the scale gap between cognitive neuroscience and cell biology, we developed a physical...
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