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Article

Mitochondrial DNA sequence data reveals association of haplogroup U with psychosis in bipolar disorder.

Journal of psychiatric research - 1 Jan 2017

Frye Mark A, Ryu Euijung, Nassan Malik, Jenkins Gregory D, Andreazza Ana C, Evans Jared M, McElroy Susan L, Oglesbee Devin, Highsmith W Edward, Biernacka Joanna M

Abstract excerpt

Converging genetic, postmortem gene-expression, cellular, and neuroimaging data implicate mitochondrial dysfunction in bipolar disorder. This study was conducted to investigate whether mitochondrial DNA (mtDNA) haplogroups and single nucleotide variants (SNVs) are associated with sub-phenotypes of bipolar disorder. MtDNA from 224 patients with Bipolar I disorder (BPI) was sequenced, and association of sequence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27770741
DOI: 10.1016/j.jpsychires.2016.09.027

Genes

BPI

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