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Peripheral and central glucose utilizations modulated by mitochondrial DNA 10398A in bipolar disorder.

Psychoneuroendocrinology - 1 May 2015

Li Cheng-Ta, Bai Ya-Mei, Hsieh Jen-Chuen, Lee Hsin-Chen, Yang Bang-Hung, Chen Mu-Hong, Lin Wei-Chen, Tsai Chia-Fen, Tu Pei-Chi, Wang Shyh-Jen, Su Tung-Ping

Abstract excerpt

Bipolar disorder (BD) is highly heritable and associated with dysregulation of brain glucose utilizations (GU). The mitochondrial DNA (mtDNA) 10398A polymorphism, as a reported BD risk factor, leads to deficient glycolytic energy production by affecting mitochondrial matrix pH and intracellular calcium levels. However, whether mtDNA-10398A has functional effects on the brain and how our body responds remain...

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PMID: 25727318
DOI: 10.1016/j.psyneuen.2015.02.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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