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Single-cell analysis reveals that GFAP+ dedifferentiated Schwann cells promote tumor progress in PNI-positive distal cholangiocarcinoma via lactate/HMGB1 axis

2024-12-10

Abstract excerpt

<title>Abstract</title> <p>Distal cholangiocarcinoma (dCCA) is a highly lethal malignancy that accounts for approximately 40% of patients with primary cholangiocarcinoma. Remarkable cellular heterogeneity and perineural invasion (PNI) are two typical features of dCCA. Deciphering the complex interplay between neoplastic and neural cells is crucial for understanding the mechanisms propelling PNI-positive dCCA prog...

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Literature Corpus work
0e74ec7d-0097-50e9-9ef7-6e10f3f8cfdc
DOI
10.21203/rs.3.rs-5240585/v1
Open publication

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Single-cell analysis reveals that GFAP+ dedifferentiated Schwann cells promote tumor progress in PNI-positive distal cholangiocarcinoma via lactate/HMGB1 axisDOI 10.21203/rs.3.rs-5240585/v1
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