Article
Mutually constructive roles of Ail and LPS in Yersinia pestis serum survival.
Molecular microbiology - 1 Sept 2020
Singh Chandan, Lee Hwayoung, Tian Ye, Schesser Bartra Sara, Hower Suzanne, Fujimoto Lynn M, Yao Yong, Ivanov Sergey A, Shaikhutdinova Rima Z, Anisimov Andrey P, Plano Gregory V, Im Wonpil, Marassi Francesca M
Abstract excerpt
The outer membrane is a key virulence determinant of gram-negative bacteria. In Yersinia pestis, the deadly agent that causes plague, the protein Ail and lipopolysaccharide (LPS)6 enhance lethality by promoting resistance to human innate immunity and antibiotics, enabling bacteria to proliferate in the human host. Their functions are highly coordinated. Here we describe how they cooperate to promote pathogenesis....
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