Aminoglycoside antibiotics perturb physiologically important microRNA contributing to drug toxicity

Abstract excerpt

<h4>ABSTRACT</h4> miRNAs are key non-protein coding regulators of gene expression in various pathophysiological conditions. Targeting miRNA with small molecules offer an unconventional approach, where clinically active compounds with RNA binding activity can be tested for their ability to modulate miRNA levels and thus for drug repositioning. Aminoglycoside antibiotics are highly effective microbicidal RNA bindin...

Topics

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• Aminoglycosides
• Anti-Bacterial Agents
• Base Sequence
• Cell Death
• Drug Hypersensitivity
• Hair Cells, Auditory
• Mitochondria
• Molecular Sequence Data

Identifiers and source

Literature Corpus work

d614c061-27fb-5109-8d52-9655086d8df2

DOI

10.1101/137935