Article

Pyroptosis Accelerates Spiral Ganglion Neuronal Degeneration Induced by Aminoglycosides in the Cochlea

2021-12-28

Abstract excerpt

<title>Abstract</title> <p>Background In aminoglycoside-induced hearing loss, damage to spiral ganglion neurons (SGNs) accelerates gradually after the acute outer hair cell death, accompanied by macrophage infiltration and cytokine release. Pyroptosis plays a critical role in neurodegenerative diseases. Here, we explored the potential role of pyroptosis in SGN degeneration. Methods C57BL/6J mice were randomly d...

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Literature Corpus work: 80a45efc-3a2d-5735-b5e6-190277229c2c
DOI: 10.21203/rs.3.rs-1158387/v1

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