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Integrating cell interaction with transcript factors to obtain a robust gene panel for prognostic prediction and therapies in cholangiocarcinoma

2022-04-21

Abstract excerpt

<h4>Background: </h4> The efficacy of immunotherapy in cholangiocarcinoma (CCA) is blocked by its high degree of tumor heterogeneity. Methods We constructed empirical Bayes and Markov random field models to calculate transcription factors, interaction genes, and associated signaling pathways involved in cell-cell communication using single cell RNAseq data. Then, we analyzed the immune exhaustion mechanism in the...

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Literature Corpus work
a78c3b44-825a-564e-858b-1e25a34079b8
DOI
10.21203/rs.3.rs-1568205/v1
Open publication

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