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From Complexity Theory to Clinical Action: A Trans-Scalar Systems Framework for Multimorbidity in Primary Care

2026-05-25

Abstract excerpt

<h4>Background: </h4> Multimorbidity affects approximately 25% of adults and 65% of those over 65, but clinical care remains organised around single-disease guidelines that generate fragmentation, polypharmacy, and therapeutic paralysis in complex patients. Complexity-based frameworks have established that multimorbidity represents systemic dysregulation — not an accumulation of discrete pathologies — but have not...

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Literature Corpus work
4f310464-3596-5d15-a956-ac41ed24cadf
DOI
10.20944/preprints202605.1618.v1
Open publication

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