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Article

Differential Ability of Spike Protein of SARS-CoV-2 Variants to Downregulate ACE2.

International journal of molecular sciences - 22 Jan 2024

Maeda Yosuke, Toyoda Mako, Kuwata Takeo, Terasawa Hiromi, Tokugawa Umiru, Monde Kazuaki, Sawa Tomohiro, Ueno Takamasa, Matsushita Shuzo

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 19 (COVID-19) and employs angiotensin-converting enzyme 2 (ACE2) as the receptor. Although the expression of ACE2 is crucial for cellular entry, we found that the interaction between ACE2 and the Spike (S) protein in the same cells led to its downregulation through degradation in the lysosomal compartment...

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Source

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Identifiers

PMID: 38279353
DOI: 10.3390/ijms25021353
PMCID: PMC10816870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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