Article

Trisomy 21 Drives ADARB1 Overexpression and Premature RNA Recoding in the Developing Fetal Brain

2025-11-17

Abstract excerpt

Understanding how chromosome 21 gene dosage contributes to neurodevelopmental and systemic phenotypes in trisomy 21 (T21) remains a fundamental challenge. We performed transcriptome wide RNA sequencing on fetal cortical and hippocampal tissues from 20 T21 cases and 27 euploid controls collected between 13 to 22 weeks postconception, a critical period for human brain development. Differential expression analysis re...

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Literature Corpus work: 0e00f4d4-28b2-5c20-9550-1084db9bb92f
DOI: 10.1101/2025.11.13.25339504

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