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Article

Lysosomal signalling pathways influence heart rhythm, and regulate atrial function

2024-06-11

Abstract excerpt

In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca 2+ ) release to augment sarcoplasmic reticulum [1] Ca 2+ sequestration, producing larger Ca 2+ transients. However, the role of lysosomal Ca 2+ signals in pacemaker activity, a distinct Ca 2+ -operated function of the sinoatrial node (SAN), or in the atrial myocardium has not been investigated. Pharma...

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Literature Corpus work
0dcf7a45-025a-5832-ba44-e4e55c9e0f6d
DOI
10.1101/2024.06.10.597905
Open publication

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Lysosomal signalling pathways influence heart rhythm, and regulate atrial functionDOI 10.1101/2024.06.10.597905
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