Article
Endoplasmic Reticulum Stress Is Associated With Autophagy and Cardiomyocyte Remodeling in Experimental and Human Atrial Fibrillation.
Journal of the American Heart Association - 24 Oct 2017
Wiersma Marit, Meijering Roelien A M, Qi Xiao-Yan, Zhang Deli, Liu Tao, Hoogstra-Berends Femke, Sibon Ody C M, Henning Robert H, Nattel Stanley, Brundel Bianca J J M
Abstract excerpt
BACKGROUND: Derailment of proteostasis, the homeostasis of production, function, and breakdown of proteins, contributes importantly to the self-perpetuating nature of atrial fibrillation (AF), the most common heart rhythm disorder in humans. Autophagy plays an important role in proteostasis by degrading aberrant proteins and organelles. Herein, we investigated the role of autophagy and its activation pathway in...
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