Article

Lysosomal signalling pathways influence heart rhythm, and regulate atrial function

2024-06-19

Abstract excerpt

<title>Abstract</title> <p>In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium release to augment sarcoplasmic reticulum (SR) calcium sequestration, producing larger calcium transients. However, the role of lysosomal calcium signals in pacemaker activity, a distinct calcium-operated function of the sino-atrial node (SAN) or atria, a distinct calcium-operated f...

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Literature Corpus work: 1d7d339e-5800-5f09-8b54-25f6e76ad262
DOI: 10.21203/rs.3.rs-4557026/v1

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