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Article

Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling

13 Jun 2017

Abstract excerpt

In response to virus infection, RIG-I-like receptors (RLRs) sense virus RNA and induce MAVS to form prion-like aggregates to further propagate antiviral signalling. Although monomeric MAVS recombinant protein can assemble into prion-like filaments spontaneously in vitro, endogenous MAVS in cells is prevented from aggregation until viral infection. The mechanism preventing cellular MAVS from spontaneous...

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PMID: 28607490
DOI: 10.1038/ncomms15676

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