Article

Drug repurposing for rare diseases via a gene-bridged heterogeneous knowledge graph and graph attention network

2026-06-21

Abstract excerpt

<h4>ABSTRACT</h4> Rare diseases are severely underserved by pharmacological treatments, and computational drug repurposing offers a cost-effective alternative to de novo discovery. We present a reproducible end-to-end pipeline integrating 3,961 rare disease–gene associations from Orphadata with 98,239 gene–drug records from DisGeNET through a multi-stage harmonization pipeline (HGNC symbol standardization and Rap...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0da39e84-260b-59ab-8344-c4210350b60d
DOI: 10.64898/2026.06.16.732556

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Drug repurposing for rare diseases via a gene-bridged heterogeneous knowledge graph and graph attention networkDOI 10.64898/2026.06.16.732556Read

An Integrated Knowledge Graph and Network Medicine Pipeline for Drug Repurposing: Benchmarking Across Human Diseases and Application to Amyotrophic Lateral SclerosisSemantic proximity Read

Deep Learning-Based Drug Repurposing Using Knowledge Graph Embeddings and GraphRAGSemantic proximity Read

CellAwareGNN: Single-Cell Enhanced Knowledge Graph Foundation Model for Drug Indication PredictionSemantic proximity Read

A Large-Scale Pharmacogenomic Knowledge Graph for Drug-Gene-Variant-Disease DiscoverySemantic proximity Read

Leveraging a Billion-Edge Knowledge Graph for Drug Re-purposing and Target Prioritization using Genomically-Informed SubgraphsSemantic proximity Read

Graph Network-Based Analysis of Disease-Gene-Drug Associations: Zero-Shot Disease-Drug Prediction and Analysis StrategiesSemantic proximity Read

A Literature-Based Knowledge Graph Embedding Method for Identifying Drug Repurposing Opportunities in Rare DiseasesSemantic proximity Read

NetMedGPT - A network medicine foundation model for extensive disease mechanism mining and drug repurposingSemantic proximity Read

Integrating and formatting biomedical data as pre-calculated knowledge graph embeddings in the BiotequeSemantic proximity Read

Knowledge Graphs and Explainable AI for Drug Repurposing on Rare DiseasesSemantic proximity Read

Task-Driven Knowledge Graph Filtering Improves Prioritizing Drugs for RepurposingSemantic proximity Read

Clinical Trial and Ontology-Derived Positive and Negative Benchmark Datasets for Drug Repurposing Across Rare DiseasesSemantic proximity Read