Article

A Large-Scale Pharmacogenomic Knowledge Graph for Drug-Gene-Variant-Disease Discovery

2025-09-25

Abstract excerpt

<h4>A bstract </h4> Precision therapeutics depends on the ability to reason jointly over genes, variants, drugs, diseases, adverse drug reactions (ADRs), and molecular pathways without contaminating evaluation with future knowledge. I present a large-scale pharmacogenomic knowledge graph (PGx-KG) that integrates PharmGKB, ClinVar, SIDER, and Reactome—harmonized to HGNC, RxNorm, MeSH, and ChEBI identifiers—yieldin...

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Identifiers and source

Literature Corpus work: 65f4981d-383a-58b2-89be-68fc60590341
DOI: 10.1101/2025.09.24.25336269

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