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Article

fcfdr: an R package to leverage continuous and binary functional genomic data in GWAS.

BMC bioinformatics - 30 Jul 2022

Hutchinson Anna, Liley James, Wallace Chris

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) are limited in power to detect associations that exceed the stringent genome-wide significance threshold. This limitation can be alleviated by leveraging relevant auxiliary data, such as functional genomic data. Frameworks utilising the conditional false discovery rate have been developed for this purpose, and have been shown to increase power for GWAS discovery...

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PMID: 35907789
DOI: 10.1186/s12859-022-04838-0
PMCID: PMC9338519

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