Article

Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models

2019-05-30

Abstract excerpt

Therapeutic innovation for human papilloma virus-related (HPV+) head and neck squamous cell carcinomas (HNSCCs) is impaired by inadequate biomarkers and preclinical models. This study addressed both limitations using the largest panel of HPV+ HNSCC patient-derived xenografts (PDXs) and organoids described to date. Whole exome profiles of the PDXs were compared to those of HPV+ human tumors and cell lines, and gene...

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Literature Corpus work: 0d871fa2-9809-5e4a-8bea-c3469459b008
DOI: 10.1101/652537

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