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Article

Establishment and characterization of patient-derived xenografts as paraclinical models for head and neck cancer.

BMC cancer - 15 Apr 2020

Kang Han Na, Kim Jae-Hwan, Park A-Young, Choi Jae Woo, Lim Sun Min, Kim Jinna, Shin Eun Joo, Hong Min Hee, Pyo Kyoung-Ho, Yun Mi Ran, Kim Dong Hwi, Lee Hanna, Yoon Sun Och, Kim Da Hee, Park Young Min, Byeon Hyung Kwon, Jung Inkyung, Paik Soonmyung, Koh Yoon Woo, Cho Byoung Chul, Kim Hye Ryun

Abstract excerpt

BACKGROUND: We investigated whether head and neck squamous cell carcinoma (HNSCC) patient-derived xenografts (PDXs) reaffirm patient responses to anti-cancer therapeutics. METHODS: Tumors from HNSCC patients were transplanted into immunodeficient mice and propagated via subsequent implantation. We evaluated established PDXs by histology, genomic profiling, and in vivo anti-cancer efficacy testing to confirm them...

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Identifiers

PMID: 32293356
DOI: 10.1186/s12885-020-06786-5
PMCID: PMC7160896

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