Article
Development and validation of an epigenetic signature of allostatic load.
Bioscience reports - 9 Apr 2025
Chamberlain Jonviea D, Ackermann Daniel, Bochud Murielle, Booth Tom, Chapatte Laurence, Corley Janie, Cox Simon R, Harris Sarah E, Kinnaer Cassandre, Juster Robert-Paul, Locatelli Isabella, Nanchen David, Ponte Belène, Pruijm Menno, Pradervand Sylvain, Shiels Paul G, Stringhini Silvia, Nusslé Sébastien, Gonseth-Nusslé Semira
Abstract excerpt
The allostatic load (AL) concept measures physiological dysregulation in response to internal and external stressors that accumulate across the life course. AL has been consistently linked to chronic disease risk across studies. However, there is considerable variation in its operationalization. In the present study, DNA methylation (DNAm) data (using the Illumina Infinium MethylationEPIC BeadChip array) from the...
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