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Varying selection pressure for a Na <sup>+</sup> sensing site in epithelial Na <sup>+</sup> channel subunits reflect divergent roles in Na <sup>+</sup> homeostasis

2024-02-21

Abstract excerpt

The epithelial Na + channel (ENaC) emerged early in vertebrates and has played a role in Na + and fluid homeostasis throughout vertebrate evolution. We previously showed that proteolytic activation of the channel evolved at the water to land transition of vertebrates. Sensitivity to extracellular Na + , known as Na + self-inhibition, reduces ENaC function when Na + concentrations are high and is a distinctive...

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Literature Corpus work
0d731c3b-9a09-58a8-9606-4e0820a3a7c9
DOI
10.1101/2024.02.16.580691
Open publication

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Varying selection pressure for a Na <sup>+</sup> sensing site in epithelial Na <sup>+</sup> channel subunits reflect divergent roles in Na <sup>+</sup> homeostasisDOI 10.1101/2024.02.16.580691
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