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DNA methylation status classifies pleural mesothelioma cells according to their immune profile: implication for precision epigenetic therapy

18 Feb 2025

Abstract excerpt

BACKGROUND: Co-targeting of immune checkpoint inhibitors (ICI) CTLA-4 and PD-1 has recently become the new first-line standard of care therapy of pleural mesothelioma (PM) patients, with a significant improvement of overall survival (OS) over conventional chemotherapy. The analysis by tumor histotype demonstrated greater efficacy of ICI therapy compared to standard chemotherapy in non-epithelioid (non-E) vs....

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PMID: 39966970
DOI: 10.1186/s13046-025-03310-0

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