Article

Local Accumulation of Axonal Mitochondria in the Optic Nerve Glial Lamina Precedes Myelination

2021-02-25

Abstract excerpt

Mitochondria are essential for neurons and must be optimally distributed along their axon to fulfil local functions. A high density of mitochondria has been observed in retinal ganglion cell (RGC) axons of an unmyelinated region of the optic nerve, called the glial lamina (GL) in mouse (lamina cribrosa in human). In glaucoma, the world’s leading cause of irreversible blindness, the GL is the epicenter of RGC degen...

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Literature Corpus work: 0d187a6a-82a0-5e04-b0b4-3b845b2fbcf1
DOI: 10.1101/2021.02.25.432924

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